ChemicalBook CAS DataBase List 2-(4-(4-(4-(2-chlorophenylcarbaMoyl)phenylaMino)-5-fluoropyriMidin-2-ylaMino)phenyl)acetic acid

2-(4-(4-(4-(2-chlorophenylcarbaMoyl)phenylaMino)-5-fluoropyriMidin-2-ylaMino)phenyl)acetic acid synthesis

1synthesis methods

Product Name:2-(4-(4-(4-(2-chlorophenylcarbaMoyl)phenylaMino)-5-fluoropyriMidin-2-ylaMino)phenyl)acetic acid
CAS Number:1158838-42-6
Molecular formula:C25H19ClFN5O3
Molecular Weight:491.9

4-(2-chloro-5-fluoropyriMidin-4-ylaMino)-N-(2-chlorophenyl)benzaMide

1158838-41-5
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1197-55-3
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2-(4-(4-(4-(2-chlorophenylcarbaMoyl)phenylaMino)-5-fluoropyriMidin-2-ylaMino)phenyl)acetic acid

1158838-42-6
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Yield:1158838-42-6 575 mg

Reaction Conditions:

Stage #1: 4-((2-chloro-5-fluoropyrimidin-4-yl)amino)-N-(2-chlorophenyl)benzamide;4-aminophenylacetic acidwith hydrogenchloride in ethanol at 180; for 0.166667 h;Microwave irradiation;
Stage #2: with water;lithium hydroxide at 40; for 4 h;

References:

Aliagas-Martin, Ignacio;Burdick, Dan;Corson, Laura;Dotson, Jennafer;Drummond, Jason;Fields, Carter;Huang, Oscar W.;Hunsaker, Thomas;Kleinheinz, Tracy;Krueger, Elaine;Liang, Jun;Moffat, John;Phillips, Gail;Pulk, Rebecca;Rawson, Thomas E.;Ultsch, Mark;Walker, Leslie;Wiesmann, Christian;Zhang, Birong;Zhu, Bing-Yan;Cochran, Andrea G. [Journal of Medicinal Chemistry,2009,vol. 52,# 10,p. 3300 - 3307] Location in patent:experimental part