2-Propenoic acid, 3-cyclohexyl-2-methyl-, ethyl ester synthesis
2synthesis methods
- Product Name:2-Propenoic acid, 3-cyclohexyl-2-methyl-, ethyl ester
- CAS Number:115901-78-5
- Molecular formula:C12H20O2
- Molecular Weight:196.29
Yield:115901-78-5 93%
Reaction Conditions:
Stage #1: ethyl 2-diethoxyphosphorylpropionatewith sodium hydride in tetrahydrofuran at 0;Inert atmosphere;
Stage #2: cyclohexanecarbaldehyde in tetrahydrofuran at 25;Inert atmosphere;Horner-Wadsworth-Emmons olefination;
References:
Gemma, Sandra;Kunjir, Sanil;Sanna Coccone, Salvatore;Brindisi, Margherita;Moretti, Vittoria;Brogi, Simone;Novellino, Ettore;Basilico, Nicoletta;Parapini, Silvia;Taramelli, Donatella;Campiani, Giuseppe;Butini, Stefania [Journal of Medicinal Chemistry,2011,vol. 54,# 16,p. 5949 - 5953] Location in patent:supporting information; experimental part
