2-PYRID-3-YL-4,5-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:2-PYRID-3-YL-4,5-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC ACID
- CAS Number:116247-03-1
- Molecular formula:C9H8N2O2S
- Molecular Weight:208.24
Yield: 87%
Reaction Conditions:
with sodium hydrogencarbonate in ethanol at 90; for 12 h;
Steps:
1 Pyridine-hydrosothiazole carboxylic acid synthesis reaction of the general formula:
3 - cyanopyridine(10mmol, 1.04 g), L-cysteine hydrochloride (15 mmol), sodium bicarbonate(60 mmol) was added to a 100 mL round bottom flask and 30 mL of absolute ethanol was added and heated at 90 ° C for 12 hours until the reaction was completed.Cooled to room temperature, spin to anhydrous ethanol to milky white solid. Dissolved in water, in the ice bath conditions, slowly add hydrochloric acid solution (thickDegree of 2mol / L), to the determination of solution ρH- = 3-4, the reaction system precipitated a large number of white solid, filter, and then washed with ice water2-3 times, after drying to give the compound pyridine dihydrothiazole carboxylic acid A1, white solid in 87% yield
References:
Yunnan University;Zhao Jingfeng;Li Liang;Wan Runfang;Yang Jiaqiong;Wei Le;Liu Kai;Zhang Hongbin;Yang Xiaodong CN106632301, 2017, A Location in patent:Paragraph 0016-0021
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