1,3-Dioxolane, 4-[(dodecyloxy)methyl]-2,2-dimethyl- synthesis

Yield:117089-03-9 740 g

Reaction Conditions:

Stage #1: acetonewith boron trifluoride diethyl etherate in tetrahydrofuran at 20;Inert atmosphere;Large scale;
Stage #2: dodecyl glycidyl ether in tetrahydrofuran at 50; for 5 h;Large scale;

Steps:

1 Production of 2,2-dimethyl-4-dodecyloxymethyl-1,3-dioxolane (A02-1)

A four-necked flask equipped with a stirrer, reflux condenser, dropping funnel, nitrogen gas inlet and thermometer was charged with 1500 g of acetone and 20 g of boron trifluoride ether complex (47 vol% THF solution) and stirred at room temperature. 630 g of dodecyl glycidyl ether (A01-1) was added dropwise at 20 ° C. or lower and reacted at 50 ° C. for 5 hours. After neutralizing by adding 20 g of sodium hydrogen carbonate, the solvent was distilled off, and water was added to separate the liquid, whereby 2,2-dimethyl-4-dodecyloxymethyl-1,3-dioxolane (A02-1 ) Was obtained.

References:

JP2019/131476,2019,A Location in patent:Paragraph 0030; 0031