![](/CAS/GIF/1174046-84-4.gif)
Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate synthesis
- Product Name:Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate
- CAS Number:1174046-84-4
- Molecular formula:C10H13NO4
- Molecular Weight:211.21
![ethyl 2-cyano-5-(dimethylamino)-3-ethoxypenta-2,4-die](/CAS/20200611/GIF/1345855-03-9.gif)
1345855-03-9
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![Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate](/CAS/GIF/1174046-84-4.gif)
1174046-84-4
68 suppliers
$45.00/25mg
Yield: 67%
Reaction Conditions:
with acetic acidReflux;
Steps:
A4
[01 03j A mixture of ethyl 2-cyano-5 -(dimethylamino)-3 -ethoxypenta-2,4-dienoate (15 Og, 0.63 mol) and HOAc (600 mL) was refluxed overnight. The mixture was cooled to RT, concentrated to dryness, treated with water and washed with EtOAc (2x). The aqueous layer was made basic (pH=9-10) with NaHCO3, extracted with DCM (3x) and the combined organics were washed with brine, dried over Na2SO4, concentrated and purified by silica gel chromatography to afford ethyl 4-ethoxy-2-oxo- 1 ,2-dihydropyridine-3 -carboxylate (90 g, 67% yield).
References:
DECIPHERA PHARMACEUTICALS, LLC;FLYNN, Daniel L.;KAUFMAN, Michael D. WO2014/145004, 2014, A1 Location in patent:Paragraph 0103
![Triethyl orthoacetate](/CAS/GIF/78-39-7.gif)
78-39-7
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![Ethyl cyanoacetate](/CAS/GIF/105-56-6.gif)
105-56-6
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$10.00/5ml
![N,N-Dimethyformamide diethy acetal](/CAS/GIF/1188-33-6.gif)
1188-33-6
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$11.19/5ML
![Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate](/CAS/GIF/1174046-84-4.gif)
1174046-84-4
68 suppliers
$45.00/25mg
![Triethyl orthoacetate](/CAS/GIF/78-39-7.gif)
78-39-7
341 suppliers
$9.00/1g
![Ethyl cyanoacetate](/CAS/GIF/105-56-6.gif)
105-56-6
432 suppliers
$10.00/5ml
![Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate](/CAS/GIF/1174046-84-4.gif)
1174046-84-4
68 suppliers
$45.00/25mg
![Ethyl cyanoacetate](/CAS/GIF/105-56-6.gif)
105-56-6
432 suppliers
$10.00/5ml
![Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate](/CAS/GIF/1174046-84-4.gif)
1174046-84-4
68 suppliers
$45.00/25mg
![ethyl 2-cyano-3-ethoxycrotonate](/CAS/20180601/GIF/35260-93-6.gif)
35260-93-6
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![Ethyl 4-Ethoxy-2-oxo-1,2-dihydropyridine-3-carboxylate](/CAS/GIF/1174046-84-4.gif)
1174046-84-4
68 suppliers
$45.00/25mg