2-((2-Fluorophenyl)amino)-1,3-thiazole-4-carboxylic acid, 95% synthesis

2synthesis methods

Product Name:2-((2-Fluorophenyl)amino)-1,3-thiazole-4-carboxylic acid, 95%
CAS Number:1176721-71-3
Molecular formula:C10H7FN2O2S
Molecular Weight:238.24

Ethyl 4-((2-fluorophenyl)amino)-3,5-thiazolecarboxylate, 95%

1366234-05-0
7 suppliers
inquiry

2-((2-Fluorophenyl)amino)-1,3-thiazole-4-carboxylic acid, 95%

1176721-71-3
7 suppliers
$355.25/1g

Yield:-

Reaction Conditions:

Stage #1: ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylatewith sodium hydroxide in ethanol at 65;
Stage #2: with hydrogenchloride in water;Cooling with ice bath;

Steps:

a.2.2

To round-bottomed flask charged with ethyl 2-[(2-fluorophenyl)amino]-1 ,3-thiazole-4- carboxylate (4.26 g, 16 mmol) and EtOH (2.4 mL) was added NaOH (16 mL, 32.0 mmol). The reaction mixture was stirred at 65 °C overnight. The ethanol was removed via rotoevaporation. The resulting material was diluted with H₂0 (10 mL) and extracted with EtOAc (2 x 20 mL). The aq layer was acidified with 2N HCI, chilled in an ice bath, and filtered to collect the titled compound as a brown solid (2 g, 8.39 mmol). MS (ES) m/e 239 [M+H]+.

References:

WO2012/37351,2012,A1 Location in patent:Page/Page column 38

656-32-6
105 suppliers
$19.00/5g

1176721-71-3
7 suppliers
$355.25/1g

References