4-Chloro-6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)-2,2''-bipyrimidine synthesis

Yield:1177447-87-8 90%

Reaction Conditions:

with sodium hydroxide in toluene at 55; for 2 h;

Steps:

1

Process for conversion of compound (1) to (2) (stage 1)Sodium hydroxide (1 eq) was added to ethylene glycol mono tert-butyl ether (3 eq) in toluene (7 vol). Compound (1) (1 eq) was added and the reaction mixture heated at 55°C for 2 hours. After completion of the reaction, the mixture was acidified with a 1:1 mixture of concentrated HCl and water (0.4 vol) to pH 2. The organic layer was separated and washed with water (5 vol). The toluene was distilled off at 40⁰C under vacuum (lOmbar) and the product (compound (2)) was obtained as a light brown solid (molar yield = 90%).

References:

WO2009/98517,2009,A1 Location in patent:Page/Page column 16