2-Chloro-1-(piperazin-1-yl)ethan-1-one Trifluoroacetic Acid synthesis

Yield:-

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20;

Steps:

2
Treatment of tert-butyl 4-(chloroacetyl)piperazine- 1 -carboxylate (An et al. ,Tetrahedron, 1998, 54, 3999) with excess trifluoroacetic acid in Cη₂CI₂ at room temperature, followed by removal of the solvent under vacuum gave crude 4-(chloroacetyl)-l- piperazinium trifluoroacetate: ¹H NMR (DMSO-dg) δ 8.94 (br s, exchangeable with D₂O, 2H), 4.44 (s, 2H), 3.66 (m, 4H), 3.13 (m, 4H), MS (APCI⁺) 163.5 (MH⁺).

References:

AUCKLAND UNISERVICES LIMITED WO2009/120094, 2009, A2 Location in patent:Page/Page column 86