ChemicalBook CAS DataBase List (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate

(S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate synthesis

2synthesis methods

Product Name:(S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate
CAS Number:1189152-81-5
Molecular formula:C15H20BrNO2
Molecular Weight:326.23

1122-91-4
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$9.00/10g

(S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate

1189152-81-5
24 suppliers
$174.00/100mg

Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: methanol / 20 °C
2.1: sodium tetrahydroborate / methanol / 0 - 20 °C
3.1: triethylamine / dichloromethane / 0 - 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
4.2: 0.17 h / -78 °C
5.1: tetrahydrofuran / 0.5 h / 20 °C
6.1: caesium carbonate; C₇₀H₆₈CoN₈O₈ / 1,4-dioxane / 24 h / 60 °C / Inert atmosphere; Schlenk technique

References:

Wang, Yong;Wen, Xin;Cui, Xin;Zhang, X. Peter [Journal of the American Chemical Society,2018,vol. 140,# 14,p. 4792 - 4796]

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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1189152-81-5
24 suppliers
$174.00/100mg

References