3-Pyridinecarboxylic acid, 2-fluoro-1,6-dihydro-6-oxo-, methyl ester synthesis

Yield:1189757-67-2 69%

Reaction Conditions:

with chloro-trimethyl-silane;sodium iodide in acetonitrile at 20; for 17 h;

References:

Ando, Makoto;Sato, Nagaaki;Nagase, Tsuyoshi;Nagai, Keita;Ishikawa, Shiho;Takahashi, Hirobumi;Ohtake, Norikazu;Ito, Junko;Hirayama, Mioko;Mitobe, Yuko;Iwaasa, Hisashi;Gomori, Akira;Matsushita, Hiroko;Tadano, Kiyoshi;Fujino, Naoko;Tanaka, Sachiko;Ohe, Tomoyuki;Ishihara, Akane;Kanatani, Akio;Fukami, Takehiro [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 16,p. 6106 - 6122] Location in patent:experimental part