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5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxylic acid synthesis

5synthesis methods
benzyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxylate

1190392-30-3
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5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxylic acid

1190392-24-5
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Yield:1190392-24-5 100%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in ethanol; for 4 h;Inert atmosphere;

References:

Moyes, Christopher R.;Berger, Richard;Goble, Stephen D.;Harper, Bart;Shen, Dong-Ming;Wang, Liping;Bansal, Alka;Brown, Patricia N.;Chen, Airu S.;Dingley, Karen H.;Di Salvo, Jerry;Fitzmaurice, Aileen;Gichuru, Loise N.;Hurley, Amanda L.;Jochnowitz, Nina;Miller, Randall R.;Mistry, Shruty;Nagabukuro, Hiroshi;Salituro, Gino M.;Sanfiz, Anthony;Stevenson, Andra S.;Villa, Katherine;Zamlynny, Beata;Struthers, Mary;Weber, Ann E.;Edmondson, Scott D. [Journal of Medicinal Chemistry,2014,vol. 57,# 4,p. 1437 - 1453]