1H-1,2,3-Triazole-1-acetic acid, α-[(dimethylamino)methylene]-, ethyl ester synthesis
- Product Name:1H-1,2,3-Triazole-1-acetic acid, α-[(dimethylamino)methylene]-, ethyl ester
- CAS Number:1192674-65-9
- Molecular formula:C9H14N4O2
- Molecular Weight:210.23
Yield:1192674-65-9 45.9%
Reaction Conditions:
at 60; for 1 h;Inert atmosphere;
Steps:
1.2 Step 2: Synthesis of ethyl 3-(dimethylamino)-2-(1H-1,2,3-triazol-1-yl)acrylate (Intermediate 1B)
Ethyl 2-(1H-1,2,3-triazol-1-yl)acetate (100 g, 0.64 mol), DMA (100 mL) was placed in a single-necked flask, and the reaction was stirred at 60 ° C for 1 hour. After the reaction was completed, the reaction solution was cooled to room temperature, and concentrated to dryness under reduced pressure, and extracted with 300 mL of water and 300 mL of dichloromethane. The organic phase was concentrated to methylene chloride. Stir at room temperature for 1 hour, filter,To give 62.2g of the title product as a pale yellow solid, yield: 45.9%.
References:
CN109694380,2019,A Location in patent:Paragraph 0173-0174; 0177-0178
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