ChemicalBook CAS DataBase List benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate synthesis

13synthesis methods

Product Name:benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate
CAS Number:1194550-67-8
Molecular formula:C36H30Cl2N2O7S
Molecular Weight:705.6

82278-73-7 Synthesis

82278-73-7
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benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

1194550-67-8
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 9 h / 100 °C
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
3: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 0 °C
4: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C
5: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

References:

Zhong, Min;Gadek, Thomas R.;Bui, Minna;Shen, Wang;Burnier, John;Barr, Kenneth J.;Hanan, Emily J.;Oslob, Johan D.;Yu, Chul H.;Zhu, Jiang;Arkin, Michelle R.;Evanchik, Marc J.;Flanagan, W. Mike;Hoch, Ute;Hyde, Jennifer;Prabhu, Saileta;Silverman, Jeffrey A.;Wright, Jasmin [ACS Medicinal Chemistry Letters,2012,vol. 3,# 3,p. 203 - 206]

77095-51-3 Synthesis