1H-Benzimidazole, 2-(4-fluorophenyl)-6-(trifluoromethyl)- synthesis
1synthesis methods
- Product Name:1H-Benzimidazole, 2-(4-fluorophenyl)-6-(trifluoromethyl)-
- CAS Number:1196131-36-8
- Molecular formula:C14H8F4N2
- Molecular Weight:280.22
Yield:1196131-36-8 46.4%
Reaction Conditions:
Stage #1: 4-fluorobenzaldehydewith sodium metabisulfite in ethanol;water;Cooling;
Stage #2: 4-(trifluoromethyl)-1,2-phenylenediamine in N,N-dimethyl-formamide at 120; for 4 h;
References:
Goeker, Hakan;Alp, Mehmet;Ates-Alagoez, Zeynep;Yildiz, Sulhiye [Journal of Heterocyclic Chemistry,2009,vol. 46,# 5,p. 936 - 948] Location in patent:experimental part