ChemicalBook CAS DataBase List (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

(2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE synthesis

4synthesis methods

Product Name:(2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
CAS Number:120016-98-0
Molecular formula:C44H49F3N5O9P
Molecular Weight:879.86

102691-36-1 Synthesis

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite

102691-36-1
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Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-

120016-97-9
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(2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-5-(3-(2,2,2-TRIFLUOROACETAMIDO)PROP-1-YNYL)-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE

120016-98-0
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Yield:120016-98-0 83%

Reaction Conditions:

with bis-diisopropylammonium tetrazolide in dichloromethane at 20; for 3 h;Inert atmosphere;

References:

Sindbert, Simon;Kalinin, Stanislav;Nguyen, Hien;Kienzler, Andrea;Clima, Lilia;Bannwarth, Willi;Appel, Bettina;Mueller, Sabine;Seidel, Claus A. M. [Journal of the American Chemical Society,2011,vol. 133,# 8,p. 2463 - 2480] Location in patent:experimental part

AcetaMide, 2,2,2-trifluoro-N-2-propynyl-

14719-21-2
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120016-98-0
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References

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120016-97-9
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References