ChemicalBook CAS DataBase List (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride synthesis

12synthesis methods

Product Name:(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride
CAS Number:1204818-19-8
Molecular formula:C10H11ClF3NO2
Molecular Weight:269.648

486460-00-8 Synthesis

Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid

486460-00-8
338 suppliers
$14.00/5g

(R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride

1204818-19-8
75 suppliers
$28.00/100mg

Yield: 82.8%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 20; for 4 h;

Steps:

7
Example 7 1.0 g (3.0 mmol) of R-beta-t-butoxyl carbonyl amino-2,4,5-trifluorophenylbutyric acid (Ic) was added to 20 mL of the mixture of ethyl acetate and HCl (2 M). The mixture was stirred for 4 hours at room temperature. The solution was concentrated to half its volume at low temperature, and crystals precipitated from the solution. The resulting precipitates were collected by filtration and dried to obtain 0.67 g of R-beta-amino-2,4,5-trifluorophenylbutyric acid hydrochloride salt (Ia). Melting point: 204.5-207.5° C. [a]_D²⁵=-6.8° (C=0.8, methanol). Yield: 82.8%.

References:

Jiangsu Hengrui Medicine Co., Ltd. US2011/130587, 2011, A1 Location in patent:Page/Page column 5