5-Carbamoyl-thiophene-2-carboxylic acid methyl ester synthesis

3synthesis methods

Product Name:5-Carbamoyl-thiophene-2-carboxylic acid methyl ester
CAS Number:1206087-41-3
Molecular formula:C7H7NO3S
Molecular Weight:185.2

50340-79-9 Synthesis

5-(METHOXYCARBONYL)THIOPHENE-2-CARBOXYLIC ACID

50340-79-9
89 suppliers
$24.00/250mg

5-Carbamoyl-thiophene-2-carboxylic acid methyl ester

1206087-41-3
7 suppliers
inquiry

Yield:1206087-41-3 1.42 g

Reaction Conditions:

Stage #1: thiophene-2,5-dicarboxylic acid monomethyl esterwith 4-methyl-morpholine;isobutyl chloroformate in tetrahydrofuran at -25;
Stage #2: with ammonia in tetrahydrofuran;water at -25 - 20; for 4.5 h;

References:

Frizler, Maxim;Schmitz, Janina;Schulz-Fincke, Anna-Christina;Gütschow, Michael [Journal of Medicinal Chemistry,2012,vol. 55,# 12,p. 5982 - 5986] Location in patent:supporting information; experimental part

4565-31-5 Synthesis

4565-31-5
141 suppliers
$19.00/250mg

1206087-41-3
7 suppliers
inquiry

References

67808-64-4
113 suppliers
$19.00/250mg

1206087-41-3
7 suppliers
inquiry

References