tert-butyl 2-benzyl-2,7-diazaspiro[3.5]nonane-7-carboxylate synthesis

2synthesis methods

Product Name:tert-butyl 2-benzyl-2,7-diazaspiro[3.5]nonane-7-carboxylate
CAS Number:1206969-92-7
Molecular formula:C19H28N2O2
Molecular Weight:316.44

tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate

896464-16-7
163 suppliers
$40.00/250mg

100-39-0
421 suppliers
$10.00/10g

tert-butyl 2-benzyl-2,7-diazaspiro[3.5]nonane-7-carboxylate

1206969-92-7
26 suppliers
$45.00/2.5mg

Yield:1206969-92-7 260 mg

Reaction Conditions:

with potassium carbonate in acetonitrile at 20; for 2 h;

Steps:

1 Example 1.2-(2-benzyl-2,7-diazaspiro[3.5]nonane-7-yl)-6-trifluoromethyl-8-nitro-4H-benzo[e][1,3]thiazin-4-one

To the tert-butyl 2,7-azaspiro[3,5]nonanee-7-carboxylate (199 mg, 0.88 mmol) at room temperatureTo a solution of acetonitrile (15 mL) was added benzyl bromide (171 mg, 1 mmol) and potassium carbonate (276 mg, 2 mmol).Stir at room temperature for 2 hours.Distilled water (30 mL) was added to the reaction mixture, and ethyl acetate (20 mL×3). There are several layers in the merger.Dry over anhydrous magnesium sulfate, concentrate,Purified by silica gel column chromatography (DCM: MeOH: NH3H2O = 200: 10: 0.2) to give a pale yellow oil (260mg).

References:

CN108530447,2018,A Location in patent:Paragraph 0086; 0087

896464-16-7
163 suppliers
$40.00/250mg

100-52-7 Synthesis

100-52-7
938 suppliers
$21.30/2g

1206969-92-7
26 suppliers
$45.00/2.5mg

References