4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-(trifluoromethyl)aniline synthesis
- Product Name:4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-2-(trifluoromethyl)aniline
- CAS Number:1207314-85-9
- Molecular formula:C10H5F10N
- Molecular Weight:329.14
Yield:1207314-85-9 97.9%
Reaction Conditions:
with sodium dithionite;ammonium chloride in acetonitrile at -5 - 70; for 15 h;Autoclave;Inert atmosphere;Temperature;Reagent/catalyst;Solvent;
Steps:
1-14; 1 Example 2
To the 1000ml autoclave, add 163.8g of acetonitrile,42.5g o-amino trifluorotoluene (0.262mol), 62.3g sodium dithionite (0.315mol), 2.8g ammonium chloride (0.052mol), nitrogen replacement, then the material in the kettle was cooled to -5°C,Then, 117.5 g of 2-bromoheptafluoropropane (0.472 mol) was introduced into the autoclave, and the temperature was raised to 60-70° C. and reacted for 15 h. After the reaction was completed, the temperature was cooled to room temperature, 400 g of water was added, stirred until the salt was completely dissolved, the layers were left to stand, the water layer was separated, and the water layer was extracted with 100 g of ethyl acetate,The organic phases were combined (content 18.80%, 0.256 mol), yield 97.9% (based on o-aminotrifluorotoluene).
References:
CN114394903,2022,A Location in patent:Paragraph 0052-0082
