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2-(2,6-Difluorophenyl)-3-Fluoro-6-Methylpyridine(WXC02866) synthesis

2synthesis methods
162101-25-9 Synthesis
2,6-Difluorophenylboronic acid

162101-25-9
331 suppliers
$6.00/1g

2-(2,6-Difluorophenyl)-3-Fluoro-6-Methylpyridine(WXC02866)

1210419-18-3
12 suppliers
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Yield:1210419-18-3 97%

Reaction Conditions:

with potassium fluoride;tris-(dibenzylideneacetone)dipalladium(0);tri-tert-butyl phosphine in tetrahydrofuran;hexane;water at 60; for 1 h;

References:

Burger, Matthew T.;Han, Wooseok;Lan, Jiong;Nishiguchi, Gisele;Bellamacina, Cornelia;Lindval, Mika;Atallah, Gordana;Ding, Yu;Mathur, Michelle;Mcbride, Chris;Beans, Elizabeth L.;Muller, Kristine;Tamez, Victoriano;Zhang, Yanchen;Huh, Kay;Feucht, Paul;Zavorotinskaya, Tatiana;Dai, Yumin;Holash, Jocelyn;Castillo, Joseph;Langowski, John;Wang, Yingyun;Chen, Min Y.;Garcia, Pablo D. [ACS Medicinal Chemistry Letters,2013,vol. 4,# 12,p. 1193 - 1197] Location in patent:supporting information