(R)-(2-Amino-4-methyl-pentyl)-carbamic acid tert-butyl ester synthesis

Yield:-

Steps:

Multi-step reaction with 4 steps
1: sodium tris(acetoxy)borohydride / 24 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 h / 20 - 70 °C
3: dmap / tetrahydrofuran / 18 h / 20 °C
4: palladium 10% on activated carbon; hydrogen / methanol / 4.5 h / 2068.65 Torr

References:

Lucas, Matthew C.;Bhagirath, Niala;Chiao, Eric;Goldstein, David M.;Hermann, Johannes C.;Hsu, Pei-Yuan;Kirchner, Stephan;Kennedy-Smith, Joshua J.;Kuglstatter, Andreas;Lukacs, Christine;Menke, John;Niu, Linghao;Padilla, Fernando;Peng, Ying;Polonchuk, Liudmila;Railkar, Aruna;Slade, Michelle;Soth, Michael;Xu, Daigen;Yadava, Preeti;Yee, Calvin;Zhou, Mingyan;Liao, Cheng [Journal of Medicinal Chemistry,2014,vol. 57,# 6,p. 2683 - 2691]