ChemicalBook CAS DataBase List (R)-1-((R)-tert-butylsulfinyl)-2-(4-fluorophenyl)pyrrolidine

(R)-1-((R)-tert-butylsulfinyl)-2-(4-fluorophenyl)pyrrolidine synthesis

1synthesis methods

Product Name:(R)-1-((R)-tert-butylsulfinyl)-2-(4-fluorophenyl)pyrrolidine
CAS Number:1218989-47-9
Molecular formula:C14H20FNOS
Molecular Weight:269.38

2-Propanesulfinamide, N-[4-chloro-1-(4-fluorophenyl)butylidene]-2-methyl-, [N(E),S(S)]-

1218989-31-1
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(R)-1-((R)-tert-butylsulfinyl)-2-(4-fluorophenyl)pyrrolidine

1218989-47-9
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Yield:1218989-47-9 93%

Reaction Conditions:

with lithium triethylborohydride in tetrahydrofuran at -78 - 20; for 4 h;Inert atmosphere;optical yield given as %de;diastereoselective reaction;

References:

Reddy, Leleti Rajender;Das, Sonia G.;Liu, Yugang;Prashad, Mahavir [Journal of Organic Chemistry,2010,vol. 75,# 7,p. 2236 - 2246] Location in patent:supporting information; experimental part