1-[4-(4-Piperidinyloxy)phenyl]-1-ethanonehydrochloride synthesis
- Product Name:1-[4-(4-Piperidinyloxy)phenyl]-1-ethanonehydrochloride
- CAS Number:1219976-64-3
- Molecular formula:C13H18ClNO2
- Molecular Weight:255.7405
502499-16-3
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1219976-64-3
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Yield:1219976-64-3 220.0 mg
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20;
Steps:
19.2 Step 2:
To a solution of 4-(4-acetyl-phenoxy)-piperidine-1 -carboxylic acid tert-butyl ester (250.0 mg) in dioxane (4.0 mL) is added HCI (4 M in dioxane, 1.0 mL). The mixture is stirred overnight at room temperature and it is then concentrated to dryness to provide a white solid which is dried under vacuum to give the compound 1-[4-(Piperidin-4- yloxy)-phenyl]-ethanone hydrochloride as a white solid (220.0 mg). (0821) 1H NMR (500 MHz, DMSO-de) d = 8.63 (br. s? 2H), 7.86 - 8.01 (m, 2H), 7.04 - 7.17 (m, 2H), 4.80 (tt, J = 7.6, 3.6 Hz, 1 H), 3.21 - 3.28 (m, 2H), 3.09 (ddd, J = 12.7, 8.8, 3.5 Hz, 2H), 2.52 (s, 3H), 2.12 (ddq, J = 10.2, 7.1 , 3.5 Hz, 2H), 1.76 - 1.90 (m, 2H). LCMS: m/z 220 [M+H]+ r.t. 3.32 min. (0822) HRMS (ESI) calcd for CI3HI8CIN02 [M +H]+ 220.1332 found 220.1338.
References:
WO2019/224096,2019,A1 Location in patent:Page/Page column 67; 68
