5-Amino-1-(2,4-difluoro-phenyl)-1H-pyrazole-4-carbaldehyde synthesis

Yield:1220512-63-9 70.8%

Reaction Conditions:

with hydrogen in water;acetic acid; under 1535.79 Torr; for 9 h;Autoclave;Large scale reaction;

References:

Milburn, Robert R.;Thiel, Oliver R.;Achmatowicz, Michal;Wang, Xiang;Zigterman, Jamie;Bernard, Charles;Colyer, John T.;Divirgilio, Evan;Crockett, Rich;Correll, Tiffany L.;Nagapudi, Karthik;Ranganathan, Kumar;Hedley, Simon J.;Allgeier, Alan;Larsen, Robert D. [Organic process research and development,2011,vol. 15,# 1,p. 31 - 43] Location in patent:experimental part