ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate synthesis

3synthesis methods

Product Name:ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
CAS Number:1221186-54-4
Molecular formula:C10H8BrNO3S
Molecular Weight:302.14

238749-50-3 Synthesis

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate

238749-50-3
74 suppliers
$61.00/250mg

93-61-8
284 suppliers
$10.00/5G

ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

1221186-54-4
11 suppliers
inquiry

Yield:1221186-54-4 730 mg

Reaction Conditions:

with trichlorophosphate in 1,2-dichloro-ethane at 0 - 85;

Steps:

4.C Step C. Synthesis of ethyl 2-bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

To a mixture of ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate (720 mg, 2.6 mmol) in 1,2- dichloroethane (DCE) (20 mL) was added N-methyl-N-phenylformamide (530 mg, 3.9 mmol) and POCI₃ (600 mg, 3.9 mmol) at 0 °C. The mixture was stirred at 85 °C overnight. The reaction mixture was poured into water, extracted with EtOAc. The combined organic layer was dried over anhy. Na₂SO₄ and concentrated. The residue was purified by silica gel chromatography to give ethyl 2-bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (730 mg). LC-MS (ESI): m/z 302 (M+H)⁺.

References:

WO2020/167976,2020,A1 Location in patent:Page/Page column 78-79

4701-17-1 Synthesis

4701-17-1
299 suppliers
$6.00/1g

1221186-54-4
11 suppliers
inquiry

References

2-Propenoic acid, 2-azido-3-(5-bromo-2-thienyl)-, ethyl ester, (2Z)-

1421933-23-4
0 suppliers
inquiry

1221186-54-4
11 suppliers
inquiry

References