ChemicalBook CAS DataBase List 1-Hydroxy-1,3-dihydro-2,1-benzoxaborole-6-carboxylic acid

1-Hydroxy-1,3-dihydro-2,1-benzoxaborole-6-carboxylic acid synthesis

12synthesis methods

Product Name:1-Hydroxy-1,3-dihydro-2,1-benzoxaborole-6-carboxylic acid
CAS Number:1221343-14-1
Molecular formula:C8H7BO4
Molecular Weight:177.95

947162-60-9 Synthesis

1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonitrile

947162-60-9
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1-Hydroxy-1,3-dihydro-2,1-benzoxaborole-6-carboxylic acid

1221343-14-1
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Yield:1221343-14-1 85%

Reaction Conditions:

with hydrogenchloride in water;Inert atmosphere;Reflux;

Steps:

1

A solution of compound C (100 mg, 0.63 mmol) in cone. HCl (10 mL) was refluxed for 3 h and cooled to RT. The mixture was filtrated. The solid was washed with water, dried to give the product D as a white solid (95 mg, 85⁰Zo)-¹H NMR (300 MHz, DMSO-J₆): δ 12.92 (s, IH), 9.36 (s, IH), 8.10 (s, IH), 8.05 (d, IH), 7.54 (d, IH), 5.08 (s, 2H). LC-MS: 177 (M - I)⁺. Purity on HPLC: 50.5% (214 nm).

References:

WO2010/45503,2010,A1 Location in patent:Page/Page column 134; 135

Methyl 3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-4-methylbenzoate

1221343-13-0
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1221343-14-1
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METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE

882679-40-5
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$36.00/1g

1221343-14-1
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$50.00/10mg

References

1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbaldehyde

1195621-94-3
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1221343-14-1
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References

104-85-8 Synthesis

104-85-8
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1221343-14-1
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References