4-Methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester synthesis

3synthesis methods

Product Name:4-Methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester
CAS Number:1224465-02-4
Molecular formula:C8H9NO3
Molecular Weight:167.16

6-Amino-4-methyl-nicotinic acid methyl ester

179555-12-5
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4-Methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

1224465-02-4
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Yield:1224465-02-4 71%

Reaction Conditions:

with sulfuric acid;water;sodium nitrite at 0 - 20;Inert atmosphere;

References:

Watterson, Scott H.;Xiao, Zili;Dodd, Dharmpal S.;Tortolani, David R.;Vaccaro, Wayne;Potin, Dominique;Launay, Michele;Stetsko, Dawn K.;Skala, Stacey;Davis, Patric M.;Lee, Deborah;Yang, Xiaoxia;McIntyre, Kim W.;Balimane, Praveen;Patel, Karishma;Yang, Zheng;Marathe, Punit;Kadiyala, Pathanjali;Tebben, Andrew J.;Sheriff, Steven;Chang, Chiehying Y.;Ziemba, Theresa;Zhang, Huiping;Chen, Bang-Chi;Delmonte, Albert J.;Aranibar, Nelly;McKinnon, Murray;Barrish, Joel C.;Suchard, Suzanne J.;Murali Dhar [Journal of Medicinal Chemistry,2010,vol. 53,# 9,p. 3814 - 3830] Location in patent:experimental part

98198-48-2 Synthesis

98198-48-2
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1224465-02-4
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References

179555-10-3
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1224465-02-4
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References