ChemicalBook CAS DataBase List N-[3-[(2E)-3-(DiMethylaMino)-1-oxo-2-propen-1-yl]phenyl]-N-ethyl-forMaMide

N-[3-[(2E)-3-(DiMethylaMino)-1-oxo-2-propen-1-yl]phenyl]-N-ethyl-forMaMide synthesis

1synthesis methods

Product Name:N-[3-[(2E)-3-(DiMethylaMino)-1-oxo-2-propen-1-yl]phenyl]-N-ethyl-forMaMide
CAS Number:1227694-93-0
Molecular formula:C14H18N2O2
Molecular Weight:246.3

1227694-91-8 Synthesis

N-[3-[(2E)-3-(DiMethylaMino)-1-oxo-2-propen-1-yl]phenyl]-forMaMide

1227694-91-8
10 suppliers
$165.00/250mg

75-03-6
354 suppliers
$11.00/5g

N-[3-[(2E)-3-(DiMethylaMino)-1-oxo-2-propen-1-yl]phenyl]-N-ethyl-forMaMide

1227694-93-0
10 suppliers
$2000.00/1g

Yield:1227694-93-0 22%

Reaction Conditions:

Stage #1: N-[3-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl]formamidewith sodium hydride in N,N-dimethyl-formamide; for 1 h;Inert atmosphere;
Stage #2: ethyl iodide in N,N-dimethyl-formamide at 20;Cooling with ice-water;

References:

Radl, Stanislav;Blahovcova, Michaela;Placek, Lukas;Pekarek, Tomas;Havlicek, Jaroslav [Journal of Heterocyclic Chemistry,2010,vol. 47,# 2,p. 276 - 283] Location in patent:experimental part