ChemicalBook CAS DataBase List 2-Bromo-N-{3-[(4-methoxyphenyl)methoxy]phenyl}thieno[3,2-b]pyridin-7-amine

2-Bromo-N-{3-[(4-methoxyphenyl)methoxy]phenyl}thieno[3,2-b]pyridin-7-amine synthesis

6synthesis methods

Product Name:2-Bromo-N-{3-[(4-methoxyphenyl)methoxy]phenyl}thieno[3,2-b]pyridin-7-amine
CAS Number:1228102-89-3
Molecular formula:C21H17BrN2O2S
Molecular Weight:441.34

225385-05-7 Synthesis

Thieno[3,2-b]pyridine, 2-bromo-7-chloro-

225385-05-7
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131770-85-9 Synthesis

BenzenaMine, 3-[(4-Methoxyphenyl)Methoxy]-

131770-85-9
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2-Bromo-N-{3-[(4-methoxyphenyl)methoxy]phenyl}thieno[3,2-b]pyridin-7-amine

1228102-89-3
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Yield:1228102-89-3 80%

Reaction Conditions:

in 1,2-dichloro-ethane;tert-butyl alcohol at 85; for 72 h;Sealed tube;

Steps:

P.23 The synthesis of 2-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-b]pyridin-7-amine

The synthesis of 2-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-b]pyridin-7-amine
The compound (0.18 g, 0.80 mmol) obtained from Preparation Example 1 was dissolved in 3 ml of dichloroethane and 3 ml of t-butanol and placed into a sealed tube.
The mixture was added with the synthesized compound (198 mg, 0.80 mmol) in example of synthesis 22-4 and stirred for next 3 days at 85° C.
After cooling to room temperature, the synthesized pale brown solid was washed by diethylether and the title compound (0.25 g, 80%) was obtained as a gray solid.
¹H-NMR (400 MHz, CDCl₃); δ 8.32 (d, J=5.2 Hz, 1H), 7.50 (s, 1H), 7.34 (d, J=7.6 Hz, 2H), 7.29 (t, J=8.0 Hz, 1H), 6.92 (d, J=7.6 Hz, 2H), 6.83-6.80 (m, 4H), 5.00 (s, 2H), 3.82 (s, 3H)

References:

US2013/72482,2013,A1 Location in patent:Paragraph 0290-0292

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1228102-89-3
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References

69627-02-7
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1228102-89-3
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69627-03-8 Synthesis

69627-03-8
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References

554-84-7
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$12.00/5g

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References