![](/CAS/GIF/1228689-61-9.gif)
4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester synthesis
- Product Name:4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester
- CAS Number:1228689-61-9
- Molecular formula:C12H10BrNO3
- Molecular Weight:296.12
![Benzenepropanoic acid, 4-bromo-α-[1-(methylamino)ethylidene]-β-oxo-, methyl ester](/CAS/20180713/GIF/1423699-80-2.gif)
1423699-80-2
15 suppliers
$28.00/100mg
![4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester](/CAS/GIF/1228689-61-9.gif)
1228689-61-9
32 suppliers
$22.00/100mg
Yield:1228689-61-9 89%
Reaction Conditions:
with hydroxylamine hydrochloride;acetic acid for 2 h;Inert atmosphere;Reflux;
Steps:
I-A
To a stirred solution of I-4a (0.78 g, 2.5 mmol) in HO Ac (10 mL) was added hydroxylamine hydrochloride (0.17 g, 2.5 mmol) under nitrogen. After the addition, the solution was heated to reflux under nitrogen for 2 hrs. The solution was concentrated in vacuo to afford compound I-5a (0.66 g, yield 89%), which was used for next step without further purification.
References:
WO2013/25733,2013,A1 Location in patent:Paragraph 0404
![Benzenepropanoic acid, α-acetyl-4-broMo-β-oxo-, Methyl ester](/CAS/20180906/GIF/85963-90-2.gif)
85963-90-2
0 suppliers
inquiry
![4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester](/CAS/GIF/1228689-61-9.gif)
1228689-61-9
32 suppliers
$22.00/100mg
![Methyl acetoacetate](/CAS/GIF/105-45-3.gif)
105-45-3
647 suppliers
$5.00/5g
![4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester](/CAS/GIF/1228689-61-9.gif)
1228689-61-9
32 suppliers
$22.00/100mg
![4-Bromobenzoic acid](/CAS/GIF/586-76-5.gif)
586-76-5
483 suppliers
$10.00/1g
![4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester](/CAS/GIF/1228689-61-9.gif)
1228689-61-9
32 suppliers
$22.00/100mg
![4-Bromobenzoyl chloride](/CAS/GIF/586-75-4.gif)
586-75-4
217 suppliers
$10.00/5g
![4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester](/CAS/GIF/1228689-61-9.gif)
1228689-61-9
32 suppliers
$22.00/100mg