tert-Butyl 4-(6-(trifluoromethyl)pyridin-3-yl)piperazine-1-carboxylate synthesis
- Product Name:tert-Butyl 4-(6-(trifluoromethyl)pyridin-3-yl)piperazine-1-carboxylate
- CAS Number:1229627-83-1
- Molecular formula:C15H20F3N3O2
- Molecular Weight:331.33
57260-71-6
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Yield:1229627-83-1 53%
Reaction Conditions:
with tris-(dibenzylideneacetone)dipalladium(0);caesium carbonate;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene in tetrahydrofuran at 70;Inert atmosphere;
References:
Wodtke, Robert;Hauser, Christoph;Ruiz-Gómez, Gloria;J?ckel, Elisabeth;Bauer, David;Lohse, Martin;Wong, Alan;Pufe, Johanna;Ludwig, Friedrich-Alexander;Fischer, Steffen;Hauser, Sandra;Greif, Dieter;Pisabarro, M. Teresa;Pietzsch, Jens;Pietsch, Markus;L?ser, Reik [Journal of Medicinal Chemistry,2018,vol. 61,# 10,p. 4528 - 4560] Location in patent:supporting information