ChemicalBook CAS DataBase List (4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone

(4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone synthesis

4synthesis methods

Product Name:(4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone
CAS Number:1231819-50-3
Molecular formula:C16H17NO3
Molecular Weight:271.31

1215295-57-0 Synthesis

[4-(2-Chloroethoxy)phenyl](4-hydroxyphenyl)Methanone

1215295-57-0
6 suppliers
$1320.00/1g

74-89-5 Synthesis

74-89-5
7 suppliers
$13.44/25ML

(4-Hydroxyphenyl)[4-[2-(MethylaMino)ethoxy]phenyl]Methanone

1231819-50-3
6 suppliers
$195.00/100mg

Yield:1231819-50-3 65%

Reaction Conditions:

in methanol;water;Reflux;

Steps:

48.B Step B: (4-hydroxyphenyl)(4-(2-(methylamino)ethoxy)phenyl)methanone

According to the same procedure as example 1, step E described, (4-(2-chloroethoxy)phenyl)(4-hydroxyphenyl)methanone (2.0 g, 1.0 eq) was reacted with MeNH₂ (30% wt in water, 30 mL) in MeOH (30 mL) under reflux to give the desired product (1.4 g, 65%). ^:H NMR (400 MHz, DMSO-cf) δ 7.67 (d, J = 8.8 Hz, 2H), 7.60 (d, J = 8.8 Hz, 2H), 7.06 (d, J = 8.8 Hz, 2H), 6.85 (d, J = 8.8 Hz, 2H), 4.18 (t, J = 5.6 Hz, 2H), 2.89 (t, J = 6.0 Hz, 2H), 2.37 (s, 3H).

References:

WO2013/97773,2013,A1 Location in patent:Paragraph 0274