8-Oxo-5-aza-spiro[2.5]octane-5-carboxylic acid benzyl ester synthesis

1synthesis methods

Product Name:8-Oxo-5-aza-spiro[2.5]octane-5-carboxylic acid benzyl ester
CAS Number:1232542-21-0
Molecular formula:C15H17NO3
Molecular Weight:259.3

1232542-20-9 Synthesis

5-benzyl 7-methyl 8-oxo-5-azaspiro[2.5]octane-5,7-dicarboxylate

1232542-20-9
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8-Oxo-5-aza-spiro[2.5]octane-5-carboxylic acid benzyl ester

1232542-21-0
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$45.00/10mg

Yield:1232542-21-0 75.5%

Reaction Conditions:

with sodium chloride in water;dimethyl sulfoxide at 110; for 7 h;Inert atmosphere;Krapcho decarboalkoxylation;

References:

Kodimuthali, Arumugam;Pal, Manojit;Prasunamba, Padala Lakshmi [Beilstein Journal of Organic Chemistry,2010,vol. 6,art. no. 71] Location in patent:supporting information; experimental part