1-(cyclobutylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole synthesis
- Product Name:1-(cyclobutylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- CAS Number:1233526-47-0
- Molecular formula:C14H23BN2O2
- Molecular Weight:262.16
17247-58-4
288 suppliers
$14.00/1g
269410-08-4
390 suppliers
$5.00/1g
1233526-47-0
26 suppliers
$200.00/100mg
Yield:1233526-47-0 405 mg
Reaction Conditions:
with caesium carbonate in acetonitrile at 50;Inert atmosphere;
Steps:
51.1 first step:L-Cyclobutylmethyl-lH-pyrazole-4-boronic acid pinacol esterPreparation
1H-pyrazole-4-boronic acid pinacol ester (500 mg, 2.577 mmol),Cyclobutylmethyl bromide (768 mg, 5.153 mmol)And cesium carbonate (2.520 g, 7.734 mmol) were dissolved in acetonitrile (10 mL),The mixture was stirred under nitrogen at 50 ° C overnight,filter,Concentrate to dryness with 1-cyclobutylmethyl-1H-pyrazole-4-boronic acid pinacol ester (405 mg).
References:
CN107312005,2017,A Location in patent:Paragraph 0510; 0511; 0512
269410-08-4
390 suppliers
$5.00/1g
7051-34-5
414 suppliers
$6.00/1g
1233526-47-0
26 suppliers
$200.00/100mg
269410-08-4
390 suppliers
$5.00/1g
16408-62-1
39 suppliers
$65.00/50mg
1233526-47-0
26 suppliers
$200.00/100mg