ChemicalBook CAS DataBase List tert-butyl 8-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

tert-butyl 8-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate synthesis

6synthesis methods

Product Name:tert-butyl 8-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate
CAS Number:1234685-60-9
Molecular formula:C16H19BrN2O2
Molecular Weight:351.24

497261-38-8 Synthesis

8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE

497261-38-8
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$85.00/250mg

24424-99-5 Synthesis

24424-99-5
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$13.50/25G

tert-butyl 8-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate

1234685-60-9
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Yield:1234685-60-9 299 mg

Reaction Conditions:

with diisopropylamine in dichloromethane;

Steps:

Synthesis of 3

The compound 2 (251 mg, 1 mmol) and di-tert butyldicarbonate (262 mg, 1.2 mmol) were dissolved in dichloromethane(8 ml). Then N, N-disopropylamine (268 mg, 2mmol) was added slowly under stirring. The solution waspoured into H2O, and extracted with dichloromethane, thendried over anhydrous sodium sulfate, filtered, and evaporated.The crude product was purified by column chromatography(dichloromethane/methanol, 23/1) to give 3 (299mg, 88.9%) as a faint yellow solid.

References:

Feng, Yu;Teng, Xingxing;Gu, Jinhua;Yu, Bangwei;Luo, Yan;Ye, Lianbao [Medicinal Chemistry Research,2019,vol. 28,# 2,p. 133 - 142]