2,2-Dimethyl-2,3-dihydrobenzofuran-4-carboxylic acid synthesis

Yield:123656-35-9 100%

Reaction Conditions:

Stage #1: ethyl 2,2-dimethyl-2,3-dihydro-benzofuran-4-carboxylatewith sodium hydroxide in ethanol; for 2 h;Heating / reflux;
Stage #2: with hydrogenchloride in water;

Steps:

6.3

Ethyl 2,2-dimethyl-2,3-dihydro-benzofuran-4-carboxylic acid (10 g, 45 mmol) was heated to reflux with sodium hydroxide (16.3 ml of 10 N, 163 mmol) in ethanol (50 ml) for 2 hr. The mixture was concentrated in vacuo, diluted with water and made acidic with 12 N HCl. The precipitate was filtered and air dried (8.6 g, 100%).

References:

EP1027043,2004,B1 Location in patent:Page/Page column 20