Ethanamine, 2-(diethylphosphino)-N-[2-(diethylphosphino)ethyl]- synthesis
2synthesis methods
- Product Name:Ethanamine, 2-(diethylphosphino)-N-[2-(diethylphosphino)ethyl]-
- CAS Number:123695-26-1
- Molecular formula:C12H29NP2
- Molecular Weight:249.31
Yield:123695-26-1 94%
Reaction Conditions:
Stage #1: Diethylphosphinewith n-butyllithium in hexane;n-heptane at 0 - 35; for 1 h;Inert atmosphere;
Stage #2: N,N-bis(2-chloroethyl)-1,1,1-trimethylsilylamine in tetrahydrofuran;hexane;n-heptane at -40 - 60; for 14 h;Inert atmosphere;
Stage #3: with tetrabutyl ammonium fluoride in tetrahydrofuran;hexane;n-heptane;water at 60; for 14 h;Inert atmosphere;
References:
Elangovan, Saravanakumar;Garbe, Marcel;Jiao, Haijun;Spannenberg, Anke;Junge, Kathrin;Beller, Matthias [Angewandte Chemie - International Edition,2016,vol. 55,# 49,p. 15364 - 15368][Angew. Chem.,2016,# 128,p. 15590 - 15594] Location in patent:supporting information
