6-Chloro-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester synthesis
- Product Name:6-Chloro-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester
- CAS Number:1237838-84-4
- Molecular formula:C11H8ClF3N2O2
- Molecular Weight:292.64
Yield:1237838-84-4 78%
Reaction Conditions:
in N,N-dimethyl-formamide at 60; for 3 h;
Steps:
9.B
Step B ethyl 6-chloro-8-(trifluoromethyl)imidazo[l,2-a]pyridine-2-carboxylate[0121] 5-chloro-3-(trifluoromethyl)-2-pyridinamine (3.0 g, 15 mmol) and ethyl bromopyruvate (4.27 mL, 30.5 mmol) in N,N-dimethylformamide (50 mL) were stirred at 60 0C for 3 hours. The mixture was allowed to cool and then poured into stirring iced water. The precipitate was stirred for 5 minutes, collected by filtration, washed with water, and dried under vacuum to give the title compound (3.5 g; 78%). LCMS: m/z 293, 295 (M+l).
References:
WO2010/91411,2010,A1 Location in patent:Page/Page column 89
183610-70-0
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