7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one synthesis
- Product Name:7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
- CAS Number:1245643-21-3
- Molecular formula:C10H10BrNO2
- Molecular Weight:256.1
1451389-06-2
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Yield:1245643-21-3 2.3 g
Reaction Conditions:
in tetrahydrofuran at 60;
Steps:
7.37.2 Example 7.37 Preparation of 7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
Step 2: Into the solution of 2-(2-amino-4-bromophenyl)propan-2-ol (2.3 g) in THF (50 mL) was added CDI (1.95 g) at rt., then the mixture was warmed to 60° C. and stirred for overnight. After solvent removal, the residue was dissolved in ethyl acetate and washed with 1M of HCl(aq) and brine, and dried with dry agent. After removal of the solvent, the residue was crystallized from DCM and hexane to provide 2.3 g of 7-bromo-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one 7.37 was synthesized.
References:
KR2016/37198,2016,A Location in patent:Paragraph 3363-3364; 3367
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1245643-21-3
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