2-Butanone, 4-[6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl]- synthesis
- Product Name:2-Butanone, 4-[6-amino-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-2-yl]-
- CAS Number:1246018-36-9
- Molecular formula:C12H14N8O
- Molecular Weight:286.2926
1246018-21-2
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1246018-36-9
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Yield:1246018-36-9 37%
Reaction Conditions:
with pyridinium chlorochromate in dichloromethane at 0 - 20;Molecular sieve;
Steps:
7
EXAMPLE 74-(6-Amino-9-methyl-8-[l,2,31triazol-2-yl-9H-purin-2-yl)-butan-2-one ST4206; Molecular sieves 4A (100 mg) and PCC (59 mg, 0.273mmol) at 0°C were added to a solution of 4-(6-amino-9-methyl-8-[l,2,3]triazol-2-yl-9Η-purin-2-yl)-butan- 2-ol (25 mg, 0.086 mmol) in DCM (1.2 ml). The mixture was stirred at RT for Ih and then diluted with Et2θ at 0°C and stirred for 30 minutes. The resulting suspension was filtered through a celite pad. The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography (DCM to DCM / MeOH: 95 / 5) to afford a white powder. Yield 37%.1H NMR (CD3CN) δ: 8.1 (s, 2H), 5.9 (bs, 2H), 3.8 (s, 3H), 3.07 (t, 2H), 2.9 (t,2H), 2.2 (s, 3H).ESI-MS (m/z): 287.1 (M + H)+
References:
WO2010/106145,2010,A1 Location in patent:Page/Page column 33
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247193-36-8
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1246018-36-9
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