![](/CAS/GIF/1246562-40-2.gif)
N-[1,1'-biphenyl]-4-yl-N-(4-broMophenyl)-9,9-diMethyl-9H-Fluoren-2-aMine synthesis
- Product Name:N-[1,1'-biphenyl]-4-yl-N-(4-broMophenyl)-9,9-diMethyl-9H-Fluoren-2-aMine
- CAS Number:1246562-40-2
- Molecular formula:C33H26BrN
- Molecular Weight:516.47
![N-(4-biphenyl)-(9,9-dimethylfluoren-2--yl)Amine](/CAS/GIF/897671-69-1.gif)
897671-69-1
243 suppliers
$6.00/250mg
![1-Bromo-4-iodobenzene](/CAS/GIF/589-87-7.gif)
589-87-7
525 suppliers
$10.00/1g
![N-[1,1'-biphenyl]-4-yl-N-(4-broMophenyl)-9,9-diMethyl-9H-Fluoren-2-aMine](/CAS/GIF/1246562-40-2.gif)
1246562-40-2
140 suppliers
$15.00/1g
Yield:1246562-40-2 91.8%
Reaction Conditions:
with copper(l) iodide;1,10-Phenanthroline;potassium hydroxide in o-xylene;water at 150; for 8 h;Inert atmosphere;Ullmann Condensation;
Steps:
4.2.1 Synthesis of N-([1,1'-biphenyl]-4-yl)-N-(4-bromophenyl)-9,9-dimethyl-9H-fluoren-2-amine (1)
A mixture of N-([1,1'-biphenyl]-4-yl)-9,9-dimethyl-9H-fluoren-2-mine (1.00 g, 2.77 mmol), 1-bromo-4-iodobenzene (1.00 g, 3,53 mmol), potassium hydroxide (0.30 g, 5.38 mmol), coprous iodide (5.70mg, 0.03 mmol) and 1,10-Phenanthroline monohydrate (5.40 mg, 0.03 mmol) in ortho-xylene (30 mL) was stirred at 150 °C for 8 h under nitrogen atmosphere. After cooling to room temperature, the solution was evaporated in vacuum. The cold water was added to the mixture and finally extracted with DCM. The combined organic phase was collected, filtered and dried over MgSO4. The crude product was purified by SiO2 column chromatography using petroleum ether/dichloromethane (4:1, v/v) afforded 1 (1.31 g, 91.8 %). 1H NMR (400 MHz, CDCl3) δ 7.58 (d, J=7.5 Hz, 1H), 7.52 (t, J=7.5 Hz, 3H), 7.43 (d, J=8.7 Hz, 2H), 7.35 (dd, J=15.4, 7.4 Hz, 3H), 7.29 (d, J=8.9 Hz, 2H), 7.23 (m, 3H), 7.14 (d, J=2.0 Hz, 1H), 7.10 (d, J=8.6 Hz, 2H), 6.98 (m, 3H), 1.36 (s, 6H).
References:
Wu, Panpan;Tian, Guojian;Hu, Mingming;Lian, Hong;Dong, Qingchen;Liang, Wenting;Huang, Jinhai;Su, Jianhua [Tetrahedron,2017,vol. 73,# 31,p. 4610 - 4615]
![N-(4-biphenyl)-(9,9-dimethylfluoren-2--yl)Amine](/CAS/GIF/897671-69-1.gif)
897671-69-1
243 suppliers
$6.00/250mg
![1,4-Dibromobenzene](/CAS/GIF/106-37-6.gif)
106-37-6
467 suppliers
$9.00/5g
![N-[1,1'-biphenyl]-4-yl-N-(4-broMophenyl)-9,9-diMethyl-9H-Fluoren-2-aMine](/CAS/GIF/1246562-40-2.gif)
1246562-40-2
140 suppliers
$15.00/1g
![N-(4-biphenyl)-(9,9-dimethylfluoren-2--yl)Amine](/CAS/GIF/897671-69-1.gif)
897671-69-1
243 suppliers
$6.00/250mg
![4-Bromofluorobenzene](/CAS/GIF/460-00-4.gif)
460-00-4
606 suppliers
$6.00/10g
![N-[1,1'-biphenyl]-4-yl-N-(4-broMophenyl)-9,9-diMethyl-9H-Fluoren-2-aMine](/CAS/GIF/1246562-40-2.gif)
1246562-40-2
140 suppliers
$15.00/1g
![N-(4-biphenyl)-(9,9-dimethylfluoren-2--yl)Amine](/CAS/GIF/897671-69-1.gif)
897671-69-1
243 suppliers
$6.00/250mg
![N-[1,1'-biphenyl]-4-yl-N-(4-broMophenyl)-9,9-diMethyl-9H-Fluoren-2-aMine](/CAS/GIF/1246562-40-2.gif)
1246562-40-2
140 suppliers
$15.00/1g
![Bromobenzene](/CAS/GIF/108-86-1.gif)
108-86-1
496 suppliers
$10.00/5g
![N-[1,1'-biphenyl]-4-yl-N-(4-broMophenyl)-9,9-diMethyl-9H-Fluoren-2-aMine](/CAS/GIF/1246562-40-2.gif)
1246562-40-2
140 suppliers
$15.00/1g