![](/CAS/20180702/GIF/1251002-97-7.gif)
tert-butyl 3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate synthesis
- Product Name:tert-butyl 3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate
- CAS Number:1251002-97-7
- Molecular formula:C10H15BrN4O2
- Molecular Weight:303.16
![6,7-Dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylic acid tert-butyl ester](/CAS/GIF/1245782-69-7.gif)
1245782-69-7
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$160.00/0.25g
![tert-butyl 3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate](/CAS/20180702/GIF/1251002-97-7.gif)
1251002-97-7
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Yield:1251002-97-7 49%
Reaction Conditions:
with NBS in acetonitrile at 0 - 20;
Steps:
tert-butyl 3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate (8a)
To a solution of 7a (13.4 g, 0.06 mol) in CH3CN (150 mL) was added NBS (12.8 g, 0.072 mol) at 0 oC, and the mixture was stirred overnight at room temperature. The solution was concentrated under reduced pressure and purified by column chromatography (hexanes/EtOAc = 5/1) to obtain 8a (8.9 g, 49%) as a yellow solid. 1H NMR (CDCl3, 400 MHz): δ 1.48 (s, 9H), 3.89 (t, J = 5.2 Hz, 2H), 4.38 (t, J = 5.2 Hz, 2H), 4.57 (s, 2H).
References:
Shan, Zhenwei;Peng, Min;Fan, Houxing;Lu, Qingtao;Lu, Peng;Zhao, Chuansheng;Chen, Yilang [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 6,p. 1731 - 1735] Location in patent:supporting information; experimental part
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![tert-butyl 3-bromo-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate](/CAS/20180702/GIF/1251002-97-7.gif)
1251002-97-7
12 suppliers
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