![](/CAS/20180527/GIF/1251582-36-1.gif)
ethyl 5-bromo-3-((ethoxycarbonyl)amino)benzofuran-2-carboxylate synthesis
- Product Name:ethyl 5-bromo-3-((ethoxycarbonyl)amino)benzofuran-2-carboxylate
- CAS Number:1251582-36-1
- Molecular formula:C14H14BrNO5
- Molecular Weight:356.17
![Ethyl chloroformate](/CAS/GIF/541-41-3.gif)
541-41-3
6 suppliers
$21.00/5g
![3-AMINO-5-BROMO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER](/StructureFile/ChemBookStructure3/GIF/CB6268291.gif)
330555-71-0
40 suppliers
$117.00/100mg
![ethyl 5-bromo-3-((ethoxycarbonyl)amino)benzofuran-2-carboxylate](/CAS/20180527/GIF/1251582-36-1.gif)
1251582-36-1
7 suppliers
inquiry
Yield:1251582-36-1 100%
Reaction Conditions:
in toluene;acetonitrile;Reflux;
Steps:
38.1
A mixture of the benzofuran 38a (prepared using the method of Example 1, step 1 but replacing compound 1a with 4-bromo-2-cyanophenol, and replacing compound 1b with ethyl 2-bromoacetate (6.0 g, 1 eq) in toluene/acetonitrile (75 mL/45 mL) and ethyl chloroformate (10 mL, 5 eq) is heated at reflux overnight, then concentrated under reduced pressure to give compound 38b (7.4 g, 100%).
References:
US2010/261714,2010,A1 Location in patent:Page/Page column 64
![5-BROMO-2-HYDROXYBENZONITRILE](/CAS/GIF/40530-18-5.gif)
40530-18-5
178 suppliers
$15.00/1g
![ethyl 5-bromo-3-((ethoxycarbonyl)amino)benzofuran-2-carboxylate](/CAS/20180527/GIF/1251582-36-1.gif)
1251582-36-1
7 suppliers
inquiry
![ethyl 4-bromo-2-cyanophenoxyacetate](/CAS/20180703/GIF/328009-03-6.gif)
328009-03-6
5 suppliers
inquiry
![ethyl 5-bromo-3-((ethoxycarbonyl)amino)benzofuran-2-carboxylate](/CAS/20180527/GIF/1251582-36-1.gif)
1251582-36-1
7 suppliers
inquiry