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(2S,3R)-2-(methoxycarbonylamino)-3-methylpentanoic acid synthesis

2synthesis methods
-

Yield:1252601-88-9 58%

Reaction Conditions:

with sodium carbonate;sodium hydroxide in 1,4-dioxane at 0 - 20;

References:

Rusere, Linah N.;Lockbaum, Gordon J.;Henes, Mina;Lee, Sook-Kyung;Spielvogel, Ean;Rao, Desaboini Nageswara;Kosovrasti, Klajdi;Nalivaika, Ellen A.;Swanstrom, Ronald;Kurt Yilmaz, Nese;Schiffer, Celia A.;Ali, Akbar [Journal of Medicinal Chemistry,2020,vol. 63,# 15,p. 8296 - 8313] Location in patent:supporting information