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Cyclohexanecarboxylic acid, 4-(4-fluorophenoxy)-, trans- synthesis

1synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 4.17 h / 60 °C / Cooling with ice
2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 14 h / 20 °C
2.2: pH 3

References:

US2012/46292,2012,A1