tert-butyl (2-(4-(hydroxymethyl)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropyl)carbamate synthesis

6synthesis methods

Product Name:tert-butyl (2-(4-(hydroxymethyl)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropyl)carbamate
CAS Number:1253955-14-4
Molecular formula:C24H27N3O4
Molecular Weight:421.49

tert-butyl (3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propyl)carbamate

1253955-13-3
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tert-butyl (2-(4-(hydroxymethyl)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropyl)carbamate

1253955-14-4
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Yield:1253955-14-4 92%

Reaction Conditions:

with tetrabutyl ammonium fluoride in tetrahydrofuran;

References:

Sturdivant, Jill M.;Royalty, Susan M.;Lin, Cheng-Wen;Moore, Lori A.;Yingling, Jeffrey D.;Laethem, Carmen L.;Sherman, Bryan;Heintzelman, Geoffrey R.;Kopczynski, Casey C.;Delong, Mitchell A. [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 10,p. 2475 - 2480]

155380-11-3 Synthesis

Methyl 2-(4-(hydroxyMethyl)phenyl)acetate

155380-11-3
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1253955-14-4
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methyl 2-(4-((triisopropylsilyloxy)methyl)phenyl)acetate

1253955-08-6
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1253955-14-4
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methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate

1253955-09-7
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1253955-14-4
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2-((2-carboxy-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)ethyl)carbamoyl)benzoic acid

1253955-10-0
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1253955-14-4
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References