Pyridine, 2-hydrazinyl-4-(phenylmethoxy)-3-(trifluoromethyl)- synthesis
- Product Name:Pyridine, 2-hydrazinyl-4-(phenylmethoxy)-3-(trifluoromethyl)-
- CAS Number:1254981-28-6
- Molecular formula:C13H12F3N3O
- Molecular Weight:283.25
1254981-27-5
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Yield:1254981-28-6 90%
Reaction Conditions:
with hydrazine hydrate in 1,4-dioxane;water at 160; for 2 h;Sealed tube;
Steps:
4.4
To a solution of intermediate 3 (100 g, 277 mmol) in 1,4-dioxane (1.5 L) was added NH2NH2 hydrate (85% solution in water, 300 g, 9.11 mol), the reaction was then heatedin sealed tube at 160 °C for 2 h. The mixture was concentrated in vacuo, dissolvedDCM washed with NaHCO3. The organic layer was dried (Na2SO4), filtered and concentrated in vacuo to yield intermediate 4 (90 g, 90%), which was used without further purification.
References:
WO2015/32790,2015,A1 Location in patent:Page/Page column 33
26452-80-2
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343781-36-2
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1186194-98-8
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$15.00/250mg
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100-51-6
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