Pyridine, 2-hydrazinyl-4-(phenylmethoxy)-3-(trifluoromethyl)- synthesis

6synthesis methods

Product Name:Pyridine, 2-hydrazinyl-4-(phenylmethoxy)-3-(trifluoromethyl)-
CAS Number:1254981-28-6
Molecular formula:C13H12F3N3O
Molecular Weight:283.25

1254981-27-5 Synthesis

4-(benzyloxy)-2-chloro-3-(trifluoroMethyl)pyridine

1254981-27-5
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Pyridine, 2-hydrazinyl-4-(phenylmethoxy)-3-(trifluoromethyl)-

1254981-28-6
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Yield:1254981-28-6 90%

Reaction Conditions:

with hydrazine hydrate in 1,4-dioxane;water at 160; for 2 h;Sealed tube;

Steps:

4.4

To a solution of intermediate 3 (100 g, 277 mmol) in 1,4-dioxane (1.5 L) was added NH2NH2 hydrate (85% solution in water, 300 g, 9.11 mol), the reaction was then heatedin sealed tube at 160 °C for 2 h. The mixture was concentrated in vacuo, dissolvedDCM washed with NaHCO3. The organic layer was dried (Na2SO4), filtered and concentrated in vacuo to yield intermediate 4 (90 g, 90%), which was used without further purification.

References:

WO2015/32790,2015,A1 Location in patent:Page/Page column 33

26452-80-2 Synthesis