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(2S,4R)-tert-butyl 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidine-1-carboxylate synthesis

7synthesis methods
61478-26-0 Synthesis
BOC-HYP-OL

61478-26-0
218 suppliers
$6.00/250mg

18162-48-6 Synthesis
tert-Butyldimethylsilyl chloride

18162-48-6
666 suppliers
$9.00/5g

(2S,4R)-tert-butyl 2-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxypyrrolidine-1-carboxylate

125653-58-9
5 suppliers
inquiry

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Yield:125653-58-9 99%

Reaction Conditions:

with dmap;triethylamine in dichloromethane at 20; for 48 h;

References:

Méndez, María;Matter, Hans;Defossa, Elisabeth;Kurz, Michael;Lebreton, Sylvain;Li, Ziyu;Lohmann, Matthias;L?hn, Matthias;Mors, Hartmut;Podeschwa, Michael;Rackelmann, Nils;Riedel, Jens;Safar, Pavel;Thorpe, David S.;Sch?fer, Matthias;Weitz, Dietmar;Breitschopf, Kristin [Journal of Medicinal Chemistry,2020,vol. 63,# 5,p. 2292 - 2307] Location in patent:supporting information