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125903-90-4

6-methyl-2-[4-(trifluoromethyl)phenyl]-1H-pyrimidin-4-one synthesis

2synthesis methods
6-methyl-2-[4-(trifluoromethyl)phenyl]-1H-pyrimidin-4-one

125903-90-4
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125904-05-4 Synthesis
4-CHLORO-6-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDINE

125904-05-4
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Yield:125904-05-4 97%

Reaction Conditions:

with trichlorophosphate for 3 h;Heating;

References:

Medwid, Jeffrey B.;Paul, Rolf;Baker, Jannie S.;Brockman, John A.;Du, Mila T.;et al. [Journal of Medicinal Chemistry,1990,vol. 33,# 4,p. 1230 - 1241]