2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine synthesis

3synthesis methods

Product Name:2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS Number:1260106-29-3
Molecular formula:C16H19BN2O2
Molecular Weight:282.15

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2-phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

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Yield:1260106-29-3 84%

Reaction Conditions:

with bis-triphenylphosphine-palladium(II) chloride;potassium acetate in 1,4-dioxane; for 5 h;Inert atmosphere;Reflux;

Steps:

2 Synthesis of Intermediate 9-2

In a flask,Intermediate 9-1 (6g, 25.6mmol),United pinacolato ester (7.8g, 31mmol),Potassium acetate (6g, 60mmol),Dioxane (100ml) and bistriphenylphosphine palladium dichloride (0.5g),Under nitrogen was heated to reflux for 5 hours.cool down,concentrate,The crude product was purified by column chromatography to give the product 6.1g,Yield 84%.

References:

CN105753849,2016,A Location in patent:Paragraph 0067; 0068

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References

223463-13-6 Synthesis

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References